Section 8 Sensitivity analyses and additional outputs
8.1 Unadjusted intervention effects
TMLE estimates without covariate adjustment, each randomized arm vs. control.
8.2 Unscaled (natural-unit) intervention effects
Adjusted effects in each component’s native units, for example g/100 mL for macronutrients, µg/L or mg/L for micronutrients, and nmol/mL for HMOs, pooled intervention vs. control.
8.2.1 Targeted metabolites (tertiary, native units)
For all 581 targeted metabolites, in µM: control and intervention means, the ATE and 95% CI, percent change, native-unit P and Q, and the standardized ATE and Q (targeted_metabolites_native_units.csv).
8.2.2 Table S1
Table S1 in full: one row per trial, visit, and outcome, with each arm’s sample size and raw mean, SD, median, and quartiles in native units side by side, and the native-unit ATE, 95% CI, P, and Q (table_s1_primary_secondary_native_units.csv).
8.3 Treatment-arm prediction
Cross-validated AUC (CV-AUC) of SuperLearner models that predict randomized arm from each class of milk components, or from all classes together, by trial, arm, and visit; 0.5 is chance.